Journal article icon

Journal article

Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes.

Abstract:

Early and high-level production of IL-12 is crucial for effective immune responses against pathogens. Up until now, the cells providing this initial IL-12 have remained elusive. Here we show that a subset of human blood dendritic cells (DC) is the principal and primary source of IL-12p70 when blood leukocytes are stimulated with the TLR4-ligand LPS or with CD40-ligand. These so-called slanDC are characterized by the 6-sulfo LacNAc modification of PSGL-1, which is identified by the mAb M-DC8. ...

Expand abstract

Actions


Access Document


Authors


Journal:
Immunity
Volume:
24
Issue:
6
Pages:
767-777
Publication date:
2006-06-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
223855

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP