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A two-compartment mechanochemical model of the roles of transforming growth factor β and tissue tension in dermal wound healing

Abstract:

The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion. Recent experimental results have shown that transforming growth factor−β (TGFβ) and tissue mechanics play roles in regulating cell proliferation, differentiation and the production of extracellular materials. We have developed a 1D mathematical model that considers the interaction between the cellular, c...

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Publication date:
2011-01-01
URN:
uuid:dfb7f953-4d33-40cb-9008-1b4600ea6c0b
Local pid:
oai:eprints.maths.ox.ac.uk:1432

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