The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.

Journal article

A bioassay that measured the interleukin (IL)-12-induced production of interferon (IFN)-gamma from mouse splenocytes was used to identify a soluble factor in the supernatants of vaccinia virus (VV)-infected cells that inhibited the production of IFN-gamma. This soluble factor was expressed by 14 out of 16 VV strains including the Western Reserve (WR) strain, but strains Copenhagen and Tashkent and a mutant of strain WR called 6/2 lacked this activity. The gene encoding this activity was ident...

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Authors: Symons, J; Adams, E; Tscharke, D; Reading, P; Waldmann, H

• Publication status: Published
• Journal: Journal of general virology
• Volume: 83
• Issue: Pt 11
• Pages: 2833-2844
• Publication date: 2002-11-01
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Mice, Inbred CBA; Molecular Sequence Data; Cells, Cultured; Interleukin-18; Virulence; Chromosome Mapping; Animals; Time Factors; Gene Expression; DNA, Viral; Mice, Inbred BALB C; Disease Models, Animal; Viral Proteins; Interferon-gamma; Interleukin-12; Vaccinia; Vaccinia virus; Virus Replication; Spleen; Poxviridae; Administration, Intranasal; Cercopithecus aethiops; Mice; Cell Line; Base Sequence; Humans