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The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.

Abstract:

A bioassay that measured the interleukin (IL)-12-induced production of interferon (IFN)-gamma from mouse splenocytes was used to identify a soluble factor in the supernatants of vaccinia virus (VV)-infected cells that inhibited the production of IFN-gamma. This soluble factor was expressed by 14 out of 16 VV strains including the Western Reserve (WR) strain, but strains Copenhagen and Tashkent and a mutant of strain WR called 6/2 lacked this activity. The gene encoding this activity was ident...

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Publication status:
Published

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Authors


Symons, JA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Tscharke, DC More by this author
Reading, PC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
The Journal of general virology
Volume:
83
Issue:
Pt 11
Pages:
2833-2844
Publication date:
2002-11-05
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:dfb394a9-663b-45f8-ba45-42c586a3e750
Source identifiers:
14156
Local pid:
pubs:14156

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