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Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Abstract:

Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is based on inhibition of biosynthesis of isoprenoids but the target enzyme is unexpectedly a distinctive C. parvum enzyme dubbed nonspecific polyprenyl pyrophosphate synthase (CpNPPPS). This enzyme pr...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Arrowood, MJ More by this author
Chruszcz, M More by this author
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Journal:
Chemistry and biology
Volume:
15
Issue:
12
Pages:
1296-1306
Publication date:
2008-12-05
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
URN:
uuid:dfa22f9b-d6c7-4a26-be2c-691750a9fc2e
Source identifiers:
107886
Local pid:
pubs:107886

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