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Site-specific ADP-ribosylation of histone H2B in response to DNA 2 double strand breaks

Abstract:

ADP-ribosyltransferases (ARTs) modify proteins with single units or polymers of ADP-ribose to regulate DNA repair. However, the substrates for these enzymes are ill-defined. For example, although histones are modified by ARTs, the sites on these proteins ADP-ribosylated following DNA damage and the ARTs that catalyse these events are unknown. This, in part, is due to the lack of a eukaryotic model that contains ARTs, in addition to histone genes that can be manipulated to assess ADP-ribosylat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep43750

Authors


Rakhimova, A More by this author
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Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Pears, CJ
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Grant:
NC/K00137X/1
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
Article: 43750
Publication date:
2017
Acceptance date:
2017-01-26
DOI:
ISSN:
2045-2322
Pubs id:
pubs:673939
URN:
uri:df9cb519-ff83-49fb-9976-07a4e48bfb4b
UUID:
uuid:df9cb519-ff83-49fb-9976-07a4e48bfb4b
Local pid:
pubs:673939

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