Journal article
Risks factors for developing post-transplant diabetes after pediatric kidney transplant in a Canadian tertiary care children’s hospital between 1995-2016
- Abstract:
- Background Post-transplant diabetes mellitus (PTDM) is a serious complication in kidney transplant recipients (KTR) due to its negative impact on graft and patient survival. Although reported in 3-20% of pediatric KTR, it is not characterized as well as in adults. This study describes the incidence and risk factors associated with the development of PTDM in pediatric KTR. Methodology Retrospective cohort study of non-diabetic pediatric patients, aged 6 months to 19 years, who underwent a first kidney transplant during 1995-2016. We estimated the cumulative incidence rate and used multivariable logistic regression to identify the diabetogenic risk factors for PTDM. Results A total of 142 KTR were included in this study. The cumulative incidence of PTDM was 31% and 14.1% in the first, and second year post-transplant, respectively. Significant risk factors for PTDM in the first-year post-transplant included: dysglycemia in the first 8-30 days post-transplant (adjusted odds ratio [aOR]: 3.02, 95% CI:1.21-7.53; p=0.018) and use of sirolimus in the first 30 days post-transplant (aOR: 5.33, 95% CI: 1.16-24.35; p=0.031). No significant association was found with typical diabetogenic factors. Conclusion The incidence of PTDM is high among pediatric KTR. Independent risk factors associated with PTDM, included meeting criteria for dysglycemia or diabetes and sirolimus use in the first month post-transplant. Typical diabetogenic risk factors for type 2 diabetes were not associated with an increased risk. This study provides important information for post-transplant medical care and future research.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1016/j.jcjd.2021.05.004
Authors
- Publisher:
- Elsevier
- Journal:
- Canadian Journal of Diabetes More from this journal
- Volume:
- 45
- Issue:
- 6
- Pages:
- 481-489
- Publication date:
- 2021-05-18
- Acceptance date:
- 2021-05-10
- DOI:
- ISSN:
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1499-2671
- Language:
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English
- Keywords:
- Pubs id:
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1178294
- Local pid:
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pubs:1178294
- Deposit date:
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2021-06-16
Terms of use
- Copyright holder:
- Canadian Diabetes Association
- Copyright date:
- 2021
- Rights statement:
- © 2021 Canadian Diabetes Association.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from Elsevier at https://doi.org/10.1016/j.jcjd.2021.05.004
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