Journal article
Reprogramming the immune system for tolerance with monoclonal antibodies.
- Abstract:
-
Monoclonal antibodies to CD4, CD8 and CD11a can be used in vivo either to deplete or functionally block T cells to create a tolerance permissive environment. Short courses of non-depleting CD4 and CD8 antibodies were used to induce tolerance separately in CD4+ and CD8+ T cells either to foreign immunoglobulins, bone marrow, or skin grafts. Tolerance was obtained to minor (non-MHC) transplantation antigens without T cell depletion even in actively sensitized mice, or to MHC plus minor antigens...
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Bibliographic Details
- Journal:
- Seminars in immunology
- Volume:
- 2
- Issue:
- 6
- Pages:
- 377-387
- Publication date:
- 1990-11-01
- EISSN:
-
1096-3618
- ISSN:
-
1044-5323
- Source identifiers:
-
16460
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:16460
- UUID:
-
uuid:df916660-1ff4-4ea5-987f-717841e2176a
- Local pid:
- pubs:16460
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1990
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