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Reprogramming the immune system for tolerance with monoclonal antibodies.

Abstract:

Monoclonal antibodies to CD4, CD8 and CD11a can be used in vivo either to deplete or functionally block T cells to create a tolerance permissive environment. Short courses of non-depleting CD4 and CD8 antibodies were used to induce tolerance separately in CD4+ and CD8+ T cells either to foreign immunoglobulins, bone marrow, or skin grafts. Tolerance was obtained to minor (non-MHC) transplantation antigens without T cell depletion even in actively sensitized mice, or to MHC plus minor antigens...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Seminars in immunology
Volume:
2
Issue:
6
Pages:
377-387
Publication date:
1990-11-05
EISSN:
1096-3618
ISSN:
1044-5323
URN:
uuid:df916660-1ff4-4ea5-987f-717841e2176a
Source identifiers:
16460
Local pid:
pubs:16460

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