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Preparation and characterization of negatively charged poly(lactic-co- glycolic acid) microspheres

Abstract:

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with hydrophilic drugs have been successfully prepared by a solidin-oil-in-water (s/o/w) solvent evaporation method in the presence of anionic surfactants, sodium dodecyl sulfate (SDS), and dioctyl sodium sulfosuccinate (DSS), and nonionic surfactant polyvinyl alcohol (PVA). The effects of microencapsulation methods, surfactants types, and surfactant concentrations on the properties of microspheres were studied....

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Publisher copy:
10.1002/jps.21612

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Institution:
University of Oxford
Department:
Oxford, MPLS, Materials
Role:
Author
Journal:
Journal of Pharmaceutical Sciences
Volume:
98
Issue:
7
Pages:
2377-2389
Publication date:
2009-07-05
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
URN:
uuid:df8cfd71-9a00-4548-abf7-52d095964178
Source identifiers:
178850
Local pid:
pubs:178850

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