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Proton-assisted Amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

Abstract:

Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subsequent activation via mechanisms involving the presence of intralumenal AAs, and interaction between mTORC1 and a multiprotein assembly containing Rag GTPases and the heterotrimeric Ragulator complex...

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Authors


Ögmundsdóttir, MH More by this author
Heublein, S More by this author
Reynolds, B More by this author
Visvalingam, SM More by this author
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Journal:
PLoS ONE
Volume:
7
Issue:
5
Publication date:
2012-05-04
DOI:
EISSN:
1932-6203
URN:
uuid:df71f531-2411-4715-a764-53cf420e2426
Source identifiers:
371490
Local pid:
pubs:371490
Language:
English

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