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Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection.

Abstract:

The HIV-1 quasispecies in peripheral blood mononuclear cells (PBMC) is considered to be a mix of actively replicating, latent, and archived viruses and may be genetically distinct from HIV-1 variants in plasma that are considered to be recently produced. Here we analyzed the genetic relationship between gp160 env sequences from replication competent clonal HIV-1 variants that were isolated from PBMC and from contemporaneous HIV-1 RNA in serum and HIV-1 proviral DNA in PBMC of four longitudina...

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Publisher copy:
10.1016/j.virol.2010.06.029

Authors


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Journal:
Virology
Volume:
405
Issue:
2
Pages:
492-504
Publication date:
2010-09-01
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
Source identifiers:
112450
Language:
English
Keywords:
Pubs id:
pubs:112450
UUID:
uuid:df715cbf-5a00-4b05-b3ed-7bc5d0b66b3c
Local pid:
pubs:112450
Deposit date:
2012-12-19

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