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Journal article

How the histological structure of some lung cancers shaped almost 70 years of radiobiology

Abstract:

Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia and that hypoxic cells require significantly larger doses of ionising radiation to achieve the same cell kill, Thomlinson and Gray inspired the subsequent decades of research into better defining the mechanistic role of molecular oxygen at the time of radiation. Ultimately, the work pioneered by Thomlinson and Gra...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41416-022-02041-9

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0002-4278-8890
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0002-2335-3146
Publisher:
Springer Nature
Journal:
British Journal of Cancer More from this journal
Volume:
128
Pages:
407–412
Publication date:
2022-11-07
Acceptance date:
2022-10-11
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
1285042
Local pid:
pubs:1285042
Deposit date:
2022-10-14

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