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Na+/H+ and HCO3-/Cl- exchange in the control of intracellular pH in vivo in the spontaneously hypertensive rat.

Abstract:

1. We have previously shown that the cytosolic acid concentration changes in skeletal muscle during contraction in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats in vivo. We have now found that this change was unaffected by 20% inhaled CO2 or by 4,4'-di-isothiocyanostilbene-2,2'-disulphonate. This is evidence that HCO3- exchange in vivo is not important in the control of cytosolic acid concentration during skeletal muscle contraction in either spontaneously hypertensive or...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Thompson, CH More by this author
Williams, EM More by this author
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Journal:
Clinical science (London, England : 1979)
Volume:
81
Issue:
6
Pages:
743-750
Publication date:
1991-12-05
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:df632880-385e-4258-b72a-002646047e04
Source identifiers:
322047
Local pid:
pubs:322047

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