mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.

Journal article

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway which ensures the rapid degradation of mRNAs containing premature translation termination codons (PTCs or nonsense codons), thereby preventing the accumulation of truncated and potentially harmful proteins. In this way, the NMD pathway contributes to suppressing or exacerbating the clinical manifestations of specific human genetic disorders. Studies in model organisms have led to the identification of the effectors of the NMD ...

Expand abstract

Authors: Behm-Ansmant, I; Kashima, I; Rehwinkel, J; Saulière, J; Wittkopp, N

• Journal: FEBS letters
• Volume: 581
• Issue: 15
• Pages: 2845-2853
• Publication date: 2007-06-01
• DOI: 10.1016/j.febslet.2007.05.027
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: RNA Helicases; Mammals; RNA, Messenger; Transcription, Genetic; Models, Biological; Humans; Genetic Diseases, Inborn; Invertebrates; Codon, Nonsense; 3' Untranslated Regions; Animals; Phenotype; Evolution, Molecular; RNA Stability