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The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

Abstract:

OBJECTIVE: Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information. METHODS: 5409 knee OA patients, 4355 hip OA patients and up to 5362 healthy controls from 7 independent cohorts from the UK and Australia were genoty...

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Publication status:
Published

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Authors


Panoutsopoulou, K More by this author
Metrustry, S More by this author
Doherty, SA More by this author
Laslett, LL More by this author
Maciewicz, RA More by this author
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Journal:
Annals of the rheumatic diseases
Volume:
73
Issue:
12
Pages:
2082-2086
Publication date:
2014-12-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:df5fd1c4-9569-4063-b486-60ab1da46227
Source identifiers:
426085
Local pid:
pubs:426085

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