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The spatial organization of sequences involved in initiation and termination of eukaryotic DNA replication.

Abstract:

Nuclear DNA is looped by attachment to a matrix or cage. As this cage is the site of DNA synthesis, sequences in the loops must attach before they are replicated. We have tested whether sequences which initiate replication are usually out in the loop and attach only during S phase or whether they are attached but quiescent during most of the cell-cycle. Sequences which permit plasmids to replicate autonomously in yeast cells (ARS's) are strong candidates for initiating sequences. Four differe...

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Publication status:
Published

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Publisher copy:
10.1093/nar/12.2.1069

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nucleic acids research
Volume:
12
Issue:
2
Pages:
1069-1075
Publication date:
1984-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:df53bd14-b139-4ef9-b1a0-da8a49aa35e6
Source identifiers:
26715
Local pid:
pubs:26715

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