- Abstract:
-
Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in human heart failure and atrial fibrillation, such as action potential (AP) prolongation, increased AP triangulation, decreased intracellular calcium transient (CaT) magnitude and decreased CaT triangulation. Our goal is to investigate whether the inf...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 999.6KB)
-
- Publisher copy:
- 10.1371/journal.pone.0056359
-
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- Funding agency for:
- Walmsley, J
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 8
- Issue:
- 2
- Pages:
- e56359
- Chapter number:
- ARTN e56359
- Publication date:
- 2013-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
- URN:
-
uuid:df4fb7f5-9cb2-481c-8fbb-f3d39a3de55e
- Source identifiers:
-
387210
- Local pid:
- pubs:387210
- Copyright holder:
- Walmsley et al.
- Copyright date:
- 2013
- Notes:
- Copyright © 2013 Walmsley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study.
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