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mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study.

Abstract:

Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in human heart failure and atrial fibrillation, such as action potential (AP) prolongation, increased AP triangulation, decreased intracellular calcium transient (CaT) magnitude and decreased CaT triangulation. Our goal is to investigate whether the inf...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0056359

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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
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Funding agency for:
Mirams, GR
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Funding agency for:
Rodriguez, B
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
8
Issue:
2
Pages:
e56359
Chapter number:
ARTN e56359
Publication date:
2013-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:df4fb7f5-9cb2-481c-8fbb-f3d39a3de55e
Source identifiers:
387210
Local pid:
pubs:387210

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