N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.

Journal article

Genetic polymorphism of the carcinogen metabolizing enzyme N-acetyl transferase 2 (NAT2) may influence susceptibility to bladder cancers related to smoking or to occupational exposure to arylamine carcinogens. This article reviews the results of 21 published case-control studies of NAT2 polymorphism and bladder-cancer risk, with a total of 2700 cases and 3426 controls. The published evidence suggests that NAT2 slow acetylator phenotype or genotype may be associated with a small increase in bl...

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Authors: Green, J; Banks, E; Berrington, A; Darby, S; Deo, H

• Publication status: Published
• Journal: British journal of cancer
• Volume: 83
• Issue: 3
• Pages: 412-417
• Publication date: 2000-08-01
• DOI: 10.1054/bjoc.2000.1265
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Case-Control Studies; Genotype; Arylamine N-Acetyltransferase; Humans; Urinary Bladder Neoplasms; Genetic Predisposition to Disease; Polymorphism, Genetic; Phenotype; Disease Susceptibility; Risk; Smoking; Risk Factors; Tobacco Smoke Pollution