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Journal article

N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.

Abstract:

Genetic polymorphism of the carcinogen metabolizing enzyme N-acetyl transferase 2 (NAT2) may influence susceptibility to bladder cancers related to smoking or to occupational exposure to arylamine carcinogens. This article reviews the results of 21 published case-control studies of NAT2 polymorphism and bladder-cancer risk, with a total of 2700 cases and 3426 controls. The published evidence suggests that NAT2 slow acetylator phenotype or genotype may be associated with a small increase in bl...

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Publication status:
Published

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Publisher copy:
10.1054/bjoc.2000.1265

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit, BHF Centre of Research Excellence
Role:
Author
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Journal:
British journal of cancer
Volume:
83
Issue:
3
Pages:
412-417
Publication date:
2000-08-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:df4ccbc7-6b7e-4732-813b-d92e6fe047c2
Source identifiers:
66419
Local pid:
pubs:66419

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