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Towards a universal vaccine for avian influenza: Protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus

Abstract:

Current vaccines targeting surface proteins can drive antigenic variation resulting either in the emergence of more highly pathogenic viruses or of antigenically distinct viruses that escape control by vaccination and thereby persist in the host population. Influenza vaccines typically target the highly mutable surface proteins and do not provide protection against heterologous challenge. Vaccines which induce immune responses against conserved influenza epitopes may confer protection against...

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Journal:
Vaccine
Volume:
31
Issue:
4
Pages:
670-675
Publication date:
2013-01-11
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:df3d4332-5ffa-4d2b-9360-5d48eeb7535d
Source identifiers:
377367
Local pid:
pubs:377367
Language:
English
Keywords:

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