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Antidepressant response and the serotonin transporter gene-linked polymorphic region

Abstract:

Background: The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been proposed as a predictor of antidepressant response. Insertion or deletion of a 44bp long region gives rise to short 'S' and long 'L' forms of the promoter region, the 'S' form being associated with reduced serotonin transporter expression. Methods: A systematic review and meta-analysis was performed to clarify the effect of 5-HTTLPR on antidepressant response and remission rates. Data were obtained from 2...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Author's Original

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Publisher copy:
10.1016/j.biopsych.2010.04.034

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Institution:
University of Oxford
Oxford college:
Balliol College
Department:
Medical Sciences Division - Psychiatry
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Institution:
Yale University
Department:
Department of Psychiatry
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Institution:
Bristol-Myers Squibb, Wallingford, Connecticut
Department:
Department of Psychiatry
Publisher:
Elsevier Publisher's website
Journal:
Biological Psychiatry Journal website
Volume:
68
Issue:
6
Pages:
536–543
DOI:
ISSN:
0006-3223
URN:
uuid:df23587c-b150-4a69-a0ff-c93ae3135d82
Local pid:
ora:4013

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