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Journal article

Intrinsically disordered p53 and its complexes populate compact conformations in the gas phase.

Abstract:
Spontaneous shrinking: the intrinsically disordered tumor suppressor protein p53 was analyzed by using a combination of ion mobility mass spectrometry and molecular dynamics simulations. Structured p53 subdomains retain their overall topology upon transfer into the gas phase. When intrinsically disordered segments are introduced into the protein sequence, however, the complex spontaneously collapses in the gas phase to a compact conformation.
Publication status:
Published

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Publisher copy:
10.1002/anie.201203047
Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
52
Issue:
1
Pages:
361-365
Publication date:
2013-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:342300
UUID:
uuid:defec2ba-4aff-4218-8cd2-5caf7271a08f
Local pid:
pubs:342300
Source identifiers:
342300
Deposit date:
2013-11-17

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