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Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC

Abstract:

Backgrounds: Multiple polymorphisms affecting smoking behavior have been identified through genomewide association studies. Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants influencing smoking behavior are expected to be associated with cotinine levels. Methods: We conducted an analysis in a lung cancer case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We invest...

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Journal:
Cancer Epidemiology Biomarkers and Prevention
Volume:
20
Issue:
10
Pages:
2250-2261
Publication date:
2011-10-05
DOI:
ISSN:
1055-9965
URN:
uuid:defcafdc-81bb-4ab2-b718-76f87b355100
Source identifiers:
192913
Local pid:
pubs:192913
Language:
English

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