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Hemodynamic responses in amygdala and hippocampus distinguish between aversive and neutral cues during Pavlovian fear conditioning in behaving rats

Abstract:

Amygdala and hippocampal tissue oxygen (TO2) signals were recorded from freely-moving rats during discriminative Pavlovian fear conditioning. TO2 signals provide a close surrogate for the BOLD-fMRI signal. TO2 signals in both regions discriminated between conditioned aversive (CS+) and neutral (CS-) cues. These data challenge recent claims that hemodynamic signals cannot detect the different patterns of neuronal activity evoked by CS+ vs. CS- stimuli. Lesion and electrophysiological studies i...

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Publisher copy:
10.1111/ejn.12057

Authors


Mchugh, SB More by this author
Marques-Smith, A More by this author
Rawlins, JNP More by this author
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Journal:
European Journal of Neuroscience
Volume:
37
Issue:
3
Pages:
498-507
Publication date:
2013-02-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:defc2290-23d8-4c48-afd7-685ceb278518
Source identifiers:
384997
Local pid:
pubs:384997

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