Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.

Journal article

OBJECTIVE: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. METHODS: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I ...

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Authors: Kerkhof, H; Meulenbelt, I; Akune, T; Arden, N; Aromaa, A

• Publication status: Published
• Journal: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
• Volume: 19
• Issue: 3
• Pages: 254-264
• Publication date: 2011-03-01
• DOI: 10.1016/j.joca.2010.10.027
• EISSN: 1522-9653
• ISSN: 1063-4584
• Language: English
• Keywords: Cohort Studies; Analysis of Variance; Osteoarthritis; Case-Control Studies; Reference Standards; Female; Male; Prevalence; Humans; Phenotype