Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells.

Journal article

We have compared the adhesion of Plasmodium falciparum-infected erythrocytes to human dermal microvascular endothelial cells (HDMEC) and human umbilical vein endothelial cells (HUVEC) and have assessed the relative roles of the receptors CD36 and intercellular adhesion molecule-1 (ICAM-1). HUVEC (a cell line that expresses high levels of ICAM-1 but no CD36) mediate low levels of adhesion, whereas HDMEC (which constitutively express CD36) mediate high levels of adhesion even before ICAM-1 indu...

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Authors: McCormick, C; Craig, A; Roberts, D; Newbold, C; Berendt, A

• Publication status: Published
• Journal: Journal of clinical investigation
• Volume: 100
• Issue: 10
• Pages: 2521-2529
• Publication date: 1997-11-01
• DOI: 10.1172/jci119794
• EISSN: 1558-8238
• ISSN: 0021-9738
• Language: English
• Keywords: Plasmodium falciparum; Animals; Tumor Necrosis Factor-alpha; Cells, Cultured; Endothelium, Vascular; Antibodies, Monoclonal; Skin; Male; Antigens, CD36; Cell Adhesion; Infant, Newborn; Fibroblast Growth Factor 2; Intercellular Adhesion Molecule-1; Umbilical Veins; Microcirculation; Enzyme-Linked Immunosorbent Assay; Antigens, CD; Humans; Erythrocytes; Recombinant Proteins