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The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.

Abstract:

Estrogen receptor alpha (ERalpha) plays an important role in breast cancer. Upregulation of HIF-1alpha in ER(alpha)-positive cancers suggests that HIF-1alpha may cooperate with ERalpha to promote breast cancer progression and consequently affect breast cancer treatment. Here, we show the histone demethylase JMJD2B is regulated by both ERalpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as...

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Publication status:
Published

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Journal:
Cancer research
Volume:
70
Issue:
16
Pages:
6456-6466
Publication date:
2010-08-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:dee6d10a-2fa1-465f-8beb-57d3e0014454
Source identifiers:
71848
Local pid:
pubs:71848

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