An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis.

Journal article

BACKGROUND: Leptospirosis is an important cause of fever in the rural tropics. Since 1996, there has been a marked increase in the incidence of leptospirosis in northeastern Thailand. Although leptospirosis generally is susceptible to antibiotics, there is no consensus regarding the optimal treatment for severe leptospirosis. METHODS: An open-label, randomized comparison of parenteral cefotaxime, penicillin G sodium (hereafter known as "penicillin G"), and doxycycline for the treatment of su...

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Authors: Suputtamongkol, Y; Niwattayakul, K; Suttinont, C; Losuwanaluk, K; Limpaiboon, R

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 39
• Issue: 10
• Pages: 1417-1424
• Publication date: 2004-11-01
• DOI: 10.1086/425001
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Leptospirosis; Severity of Illness Index; Adolescent; Anti-Bacterial Agents; Cefotaxime; Humans; Aged, 80 and over; Adult; Female; Male; Doxycycline; Aged; Penicillins; Middle Aged