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Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis.

Abstract:

OBJECTIVE: To examine peripheral leukocyte Dectin-1 regulation in clinically relevant models of fungal and polymicrobial sepsis. DESIGN: Prospective animal study. SETTING: University medical school research laboratory. SUBJECTS: Age, weight, and sex matched ICR/HSD mice. INTERVENTIONS: Mice were infected with Candida albicans (1 x 10, intravenously) or were subjected to cecal ligation and puncture to induce polymicrobial sepsis. MEASUREMENTS: Blood, spleen, and peritoneal exudate were harvest...

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Publication status:
Published

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Journal:
Critical care medicine
Volume:
37
Issue:
3
Pages:
1038-1045
Publication date:
2009-03-05
DOI:
EISSN:
1530-0293
ISSN:
0090-3493
URN:
uuid:ded739f0-7433-4a4f-b4f5-2e95e62e9dc9
Source identifiers:
18878
Local pid:
pubs:18878

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