Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy.

Journal article

Individual and topographical variation in the metabolic profiles of multiple human gastrointestinal tract (GIT) biopsies have been characterized using high-resolution magic-angle spinning (HRMAS) 1H NMR spectroscopy and pattern recognition. Samples from antrum, duodenum, jejunum, ileum, and transverse colon were obtained from 8 male and 8 female participants. Each gut region generated a highly characteristic metabolic profile consistent with the varying structural and functional properties of...

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Authors: Wang, Y; Holmes, E; Comelli, E; Fotopoulos, G; Dorta, G

• Publication status: Published
• Journal: Journal of proteome research
• Volume: 6
• Issue: 10
• Pages: 3944-3951
• Publication date: 2007-10-01
• DOI: 10.1021/pr0702565
• EISSN: 1535-3907
• ISSN: 1535-3893
• Language: English
• Keywords: Biopsy; Gastrointestinal Tract; Intestines; Female; Gastric Mucosa; Magnetic Resonance Spectroscopy; Stomach; Adult; Male; Reference Values; Intestinal Mucosa; Humans