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Video Rating in Neurodegenerative Disease Clinical Trials: The Experience of PRION-1.

Abstract:

BACKGROUND/AIMS: Large clinical trials including patients with uncommon diseases involve assessors in different geographical locations, resulting in considerable inter-rater variability in assessment scores. As video recordings of examinations, which can be individually rated, may eliminate such variability, we measured the agreement between a single video rater and multiple examining physicians in the context of PRION-1, a clinical trial of the antimalarial drug quinacrine in human prion dis...

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Publisher copy:
10.1159/000339730

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Journal:
Dementia and geriatric cognitive disorders extra
Volume:
2
Issue:
1
Pages:
286-297
Publication date:
2012-01-05
DOI:
EISSN:
1664-5464
URN:
uuid:ded3b243-0466-4107-868f-0a158b7ebafb
Source identifiers:
422599
Local pid:
pubs:422599

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