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Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk.

Abstract:

Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), we analyzed 824 ALL cases and 2398 controls genotyped for 292 200 tagging SNPs. Across the genome, cumulative distribution of ROH was not significantly different between c...

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Publication status:
Published

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Authors


Hosking, FJ More by this author
Papaemmanuil, E More by this author
Sheridan, E More by this author
Kinsey, SE More by this author
Lightfoot, T More by this author
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Journal:
Blood
Volume:
115
Issue:
22
Pages:
4472-4477
Publication date:
2010-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:dec102a0-f7ae-4883-ae48-8d02cd7e8908
Source identifiers:
72287
Local pid:
pubs:72287

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