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'Naked' and hydrated conformers of the conserved core pentasaccharide of N-linked glycoproteins and its building blocks.

Abstract:

N-glycosylation of eukaryotic proteins is widespread and vital to survival. The pentasaccharide unit -Man3GlcNAc2- lies at the protein-junction core of all oligosaccharides attached to asparagine side chains during this process. Although its absolute conservation implies an indispensable role, associated perhaps with its structure, its unbiased conformation and the potential modulating role of solvation are unknown; both have now been explored through a combination of synthesis, laser spectro...

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Publication status:
Published

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Publisher copy:
10.1021/ja4056678

Authors


Cocinero, EJ More by this author
Carçabal, P More by this author
Gamblin, DP More by this author
Stanca-Kaposta, EC More by this author
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Journal:
Journal of the American Chemical Society
Volume:
135
Issue:
45
Pages:
16895-16903
Publication date:
2013-11-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:deb689f8-542d-476a-ab7d-187710da96dc
Source identifiers:
438875
Local pid:
pubs:438875

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