The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation.

Journal article

BACKGROUND: Accurate chromosome segregation depends on the establishment of correct-amphitelic-kinetochore orientation. Merotelic kinetochore orientation is an error that occurs when a single kinetochore attaches to microtubules emanating from opposite spindle poles, a condition that hinders segregation of the kinetochore to a spindle pole in anaphase. To avoid chromosome missegregation resulting from merotelic kinetochore orientation, cells have developed mechanisms to prevent or correct me...

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Authors: Gregan, J; Riedel, C; Pidoux, A; Katou, Y; Rumpf, C

• Publication status: Published
• Journal: Current biology : CB
• Volume: 17
• Issue: 14
• Pages: 1190-1200
• Publication date: 2007-07-01
• DOI: 10.1016/j.cub.2007.06.044
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Cell Cycle Proteins; Schizosaccharomyces; Methyltransferases; Multiprotein Complexes; Heterochromatin; Mitosis; Kinetochores; Chromosome Segregation; Schizosaccharomyces pombe Proteins; Meiosis; Mass Spectrometry