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Journal article

Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.

Abstract:

We provide evidence for a novel mechanism of transcriptional regulation in which the immediate-early (IE) transactivating protein of herpes simplex virus, Vmw65, is assembled into a specific DNA-binding complex together with a cellular octamer-binding factor (TRF). The assembly of Vmw65/TRF complex requires not only the core TRF recognition site, but also flanking sequences which are dispensable for TRF binding alone. We show from functional analyses that TRF binding by a motif is required bu...

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Publication status:
Published

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Authors


Goding, CR More by this author
Journal:
The EMBO journal
Volume:
7
Issue:
13
Pages:
4231-4238
Publication date:
1988-12-05
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:dea1e89f-e351-4bbd-ad6f-565842aed6c0
Source identifiers:
92939
Local pid:
pubs:92939

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