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Complications associated with recombinant tissue plasminogen activator therapy for acute ischaemic stroke.

Abstract:

Intravenous recombinant human tissue plasminogen activator (rtPA, formulated as alteplase) is the primary therapy for acute ischaemic stroke by breaking down a clot of an occluded vessel. There are several randomised controlled trials and observational studies that support the use of rtPA to improve functional outcome following acute ischaemic stroke. However, thrombolytic therapy with rtPA can be associated with a number of complications. Many of the rtPArelated complications result from its...

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Publication status:
Published

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Authors


Balami, JS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
CNS and neurological disorders drug targets
Volume:
12
Issue:
2
Pages:
155-169
Publication date:
2013-03-05
DOI:
EISSN:
1996-3181
ISSN:
1871-5273
URN:
uuid:de99b4c5-5b62-448e-893a-f6550c5a84ea
Source identifiers:
384121
Local pid:
pubs:384121

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