Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.

Journal article

The role of Ca2+ in the regulation of insulin secretion was evaluated using beta-cell-rich pancreatic islets isolated from ob/ob-mice. The glucose stimulation of the secretory activity is supposed to result from accumulation of Ca2+ in the submembrane cytoplasmic space. It is likely that this process reflects the balance between increased entry of Ca2+ into the beta-cells and an enhanced sequestration of Ca2+ in the organelle sinks. The proposed model can explain the cAMP potentiation of gluc...

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Authors: Hellman, B; Gylfe, E; Berggren, P; Andersson, T; Abrahamsson, H

• Publication status: Published
• Publisher: Informa Healthcare
• Journal: Upsala journal of medical sciences
• Volume: 85
• Issue: 3
• Pages: 321-329
• Publication date: 1980-01-01
• DOI: 10.3109/03009738009179202
• EISSN: 2000-1967
• ISSN: 0300-9734
• Language: English
• Keywords: Subcellular Fractions; Mitochondria; Blood Glucose; Islets of Langerhans; Cytoplasmic Granules; Insulin; Ion Channels; Secretory Rate; Calcium; Mice; Cyclic AMP; Membrane Potentials; Animals; Adenosine Triphosphate