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Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.

Abstract:

The role of Ca2+ in the regulation of insulin secretion was evaluated using beta-cell-rich pancreatic islets isolated from ob/ob-mice. The glucose stimulation of the secretory activity is supposed to result from accumulation of Ca2+ in the submembrane cytoplasmic space. It is likely that this process reflects the balance between increased entry of Ca2+ into the beta-cells and an enhanced sequestration of Ca2+ in the organelle sinks. The proposed model can explain the cAMP potentiation of gluc...

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Publication status:
Published

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Publisher copy:
10.3109/03009738009179202

Authors


Hellman, B More by this author
Berggren, PO More by this author
Andersson, T More by this author
Abrahamsson, H More by this author
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Publisher:
Informa Healthcare
Journal:
Upsala journal of medical sciences
Volume:
85
Issue:
3
Pages:
321-329
Publication date:
1980
DOI:
EISSN:
2000-1967
ISSN:
0300-9734
URN:
uuid:de96752c-a175-4e62-8b42-a521c5613b3f
Source identifiers:
17992
Local pid:
pubs:17992

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