Evaluation of human bone marrow stromal cell growth on biodegradable polymer/bioglass composites.

Journal article

Bone tissue engineering using human bone marrow mesenchymal stem cells (HBMCs) and biocompatible materials provides an attractive approach to regenerate bone tissue to meet the major clinical need. The aim of this study was to examine the effects of novel porous biodegradable composite materials consisting of a bioactive phase (45S5 Bioglass, 0, 5, and 40 wt%) incorporated within a biodegradable poly(dl-lactic acid) matrix, on HBMCs growth. Cell adhesion, spreading, and viability was examined...

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Authors: Yang, X; Webb, D; Blaker, J; Boccaccini, A; Maquet, V

• Publication status: Published
• Journal: Biochemical and biophysical research communications
• Volume: 342
• Issue: 4
• Pages: 1098-1107
• Publication date: 2006-04-01
• DOI: 10.1016/j.bbrc.2006.02.021
• EISSN: 1090-2104
• ISSN: 0006-291X
• Language: English
• Keywords: Bone Substitutes; Absorbable Implants; Mice, Nude; Mice; Cell Culture Techniques; Polyesters; Aged; Mesenchymal Stromal Cells; Humans; Ceramics; Adult; Female; Male; Animals; Tissue Engineering; Glass; Biocompatible Materials; Cell Differentiation; Aged, 80 and over; Osteoblasts; Cells, Cultured; Middle Aged