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Journal article

In-situ analysis of calcitonin and CGRP expression in medullary thyroid carcinoma.

Abstract:

A combination of immunocytochemistry (ICC) and in-situ hybridization (ISH) applied to formalin-fixed tissue sections was used to analyse the differential expression of calcitonin and CGRP genes, at both peptide and mRNA levels, in normal and neoplastic human thyroid C cells. Calcitonin peptide was readily detectable in normal C cells but its abundance in the neoplastic C cells of medullary thyroid carcinoma (MTC) was reduced in correlation with the degree of tumour differentiation. Conversely...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Role:
Author
Journal:
Clinical endocrinology
Volume:
33
Issue:
3
Pages:
381-390
Publication date:
1990-09-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:de7827b0-e730-4ebf-97ba-d64acbdc8098
Source identifiers:
375319
Local pid:
pubs:375319

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