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Serotonin, amygdala and fear: Assembling the puzzle

Abstract:

The fear circuitry orchestrates defense mechanisms in response to environmental threats. This circuitry is evolutionarily crucial for survival, but its dysregulation is thought to play a major role in the pathophysiology of psychiatric conditions in humans. The amygdala is a key player in the processing of fear. This brain area is prominently modulated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The 5-HT input to the amygdala has drawn particular interest because genetic an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fncir.2016.00024

Authors


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Department:
Oxford, MSD, Pharmacology
McHugh, SB More by this author
Bannerman, DM More by this author
Capogna, M More by this author
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Frontiers Media S.A. Publisher's website
Journal:
Frontiers in Neural Circuits Journal website
Volume:
10
Pages:
ARTN 24
Publication date:
2016-04-05
Acceptance date:
2016-03-21
DOI:
ISSN:
1662-5110
Pubs id:
pubs:616730
URN:
uri:de69c069-556e-481b-92b6-37ad57619c09
UUID:
uuid:de69c069-556e-481b-92b6-37ad57619c09
Local pid:
pubs:616730

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