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Journal article

Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells.

Abstract:

Human immunodeficiency virus type 1 (HIV-1)-infected T cells form a virological synapse with noninfected CD4(+) T cells in order to efficiently transfer HIV-1 virions from cell to cell. The virological synapse is a specialized cellular junction that is similar in some respects to the immunological synapse involved in T-cell activation and effector functions mediated by the T-cell antigen receptor. The immunological synapse stops T-cell migration to allow a sustained interaction between T-cell...

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Publication status:
Published

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Publisher copy:
10.1128/JVI.00835-08

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Journal:
Journal of virology
Volume:
82
Issue:
19
Pages:
9445-9457
Publication date:
2008-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:de6981ec-1b2d-4bfb-b242-37e815340beb
Source identifiers:
426313
Local pid:
pubs:426313

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