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Computationally profiling peptide: MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies

Abstract:

T-cell receptor-mimetic antibodies (TCRms) targeting disease-associated peptides presented by Major Histocompatibility Complexes (pMHCs) are set to become a major new drug modality. However, we lack a general understanding of how TCRms engage pMHC targets, which is crucial for predicting their specificity and safety. Several new structures of TCRm:pMHC complexes have become available in the past year, providing sufficient initial data for a holistic analysis of TCRms as a class of pMHC bin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2022.1080596

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
13
Article number:
1080596
Publication date:
2023-01-09
Acceptance date:
2022-12-07
DOI:
EISSN:
1664-3224
Language:
English
Keywords:
Pubs id:
1315295
Local pid:
pubs:1315295
Deposit date:
2022-12-15

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