Journal article
Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP.
- Abstract:
-
Exposure to high altitude is associated with sustained, but reversible, changes in cardiac mass, diastolic function, and high-energy phosphate metabolism. Whilst the underlying mechanisms remain elusive, tissue hypoxia increases generation of reactive oxygen species (ROS), which can stabilize hypoxia-inducible factor (HIF) transcription factors, bringing about transcriptional changes that suppress oxidative phosphorylation and activate autophagy. We therefore investigated whether oral supplem...
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- Publication status:
- Published
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Authors
Bibliographic Details
- Publisher:
- Mary Ann Liebert Inc.
- Journal:
- High altitude medicine and biology More from this journal
- Volume:
- 15
- Issue:
- 4
- Pages:
- 459-467
- Publication date:
- 2014-12-01
- DOI:
- EISSN:
-
1557-8682
- ISSN:
-
1527-0297
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:458556
- UUID:
-
uuid:de6098e1-23bd-49e2-8d5a-088a94010479
- Local pid:
-
pubs:458556
- Source identifiers:
-
458556
- Deposit date:
-
2014-08-29
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- Copyright date:
- 2014
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