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Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP.

Abstract:

Exposure to high altitude is associated with sustained, but reversible, changes in cardiac mass, diastolic function, and high-energy phosphate metabolism. Whilst the underlying mechanisms remain elusive, tissue hypoxia increases generation of reactive oxygen species (ROS), which can stabilize hypoxia-inducible factor (HIF) transcription factors, bringing about transcriptional changes that suppress oxidative phosphorylation and activate autophagy. We therefore investigated whether oral supplem...

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Publication status:
Published

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Publisher copy:
10.1089/ham.2013.1053

Authors


Publisher:
Mary Ann Liebert Inc.
Journal:
High altitude medicine and biology More from this journal
Volume:
15
Issue:
4
Pages:
459-467
Publication date:
2014-12-01
DOI:
EISSN:
1557-8682
ISSN:
1527-0297
Language:
English
Keywords:
Pubs id:
pubs:458556
UUID:
uuid:de6098e1-23bd-49e2-8d5a-088a94010479
Local pid:
pubs:458556
Source identifiers:
458556
Deposit date:
2014-08-29

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