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Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells

Abstract:

The transcriptional repressor Blimp-1 originally cloned as a silencer of type I interferon (IFN)-β gene expression controls cell fate decisions in multiple tissue contexts. Conditional inactivation in the mammary gland was recently shown to disrupt epithelial cell architecture. Here we report that Blimp-1 regulates expression of viral defense, IFN signaling and MHC class I pathways, and directly targets the transcriptional activator Stat1. Blimp-1 functional loss in 3D cultures of mammary epi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-18652-9

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-1005-438X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
St Edmund Hall
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-2004-4348
More from this funder
Grant:
090532/Z/09/Z; 102811; 08957
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 237
Publication date:
2018-01-10
Acceptance date:
2017-12-15
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:820917
URN:
uri:de5c8327-64a3-4214-a288-e20081a8f30f
UUID:
uuid:de5c8327-64a3-4214-a288-e20081a8f30f
Local pid:
pubs:820917
Language:
English
Keywords:

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