Journal article
On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
- Abstract:
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The role of peroxisome proliferator-activated receptora(PPARa)-mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 wk beforein vivocontractile function was measured using cine MRI. In isolated, perfused hearts, energetics were measured using 31P magnetic resonance spectroscopy (MRS), and glycolysis and fatty acid oxidation were measured using [3H] labeling. Compared with a normoxic, chow-fed control mouse heart, hypoxia...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.7MB, Terms of use)
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- Publisher copy:
- 10.1096/fj.201500094R
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Bibliographic Details
- Publisher:
- Federation of American Society of Experimental Biology
- Journal:
- FASEB Journal More from this journal
- Publication date:
- 2016-04-01
- Acceptance date:
- 2016-04-05
- DOI:
- EISSN:
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1530-6860
- ISSN:
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0892-6638
Item Description
- Keywords:
- Pubs id:
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pubs:618227
- UUID:
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uuid:de5ab1d3-ed13-440a-ad8d-70016b26440d
- Local pid:
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pubs:618227
- Source identifiers:
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618227
- Deposit date:
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2016-04-28
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- Copyright date:
- 2016
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