Journal article icon

Journal article

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

Abstract:

The role of peroxisome proliferator-activated receptora(PPARa)-mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 wk beforein vivocontractile function was measured using cine MRI. In isolated, perfused hearts, energetics were measured using 31P magnetic resonance spectroscopy (MRS), and glycolysis and fatty acid oxidation were measured using [3H] labeling. Compared with a normoxic, chow-fed control mouse heart, hypoxia...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1096/fj.201500094R

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and#38; Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and#38; Genetics
Role:
Author
Expand authors...
Wellcome Trust More from this funder
Malaysian Ministry of Higher Education More from this funder
Publisher:
Federation of American Society of Experimental Biology Publisher's website
Journal:
The FASEB Journal Journal website
Publication date:
2016-04-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:de5ab1d3-ed13-440a-ad8d-70016b26440d
Source identifiers:
618227
Local pid:
pubs:618227

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP