Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1.

Journal article

There is increasing evidence that human arylamine N-acetyltransferase type 1 (NAT1, EC 2.3.1.5), although first identified as a homologue of a drug-metabolising enzyme, appears to be a marker in human oestrogen receptor positive breast cancer. Mouse Nat2 is the mouse equivalent of human NAT1. The development of mouse models of breast cancer is important, and it is essential to explore the biological role of mouse Nat2. We have therefore produced mouse Nat2 as a recombinant protein and have in...

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Authors: Kawamura, A; Westwood, I; Wakefield, L; Long, H; Zhang, N

• Publication status: Published
• Journal: Biochemical pharmacology
• Volume: 75
• Issue: 7
• Pages: 1550-1560
• Publication date: 2008-04-01
• DOI: 10.1016/j.bcp.2007.12.012
• EISSN: 1873-2968
• ISSN: 0006-2952
• Language: English
• Keywords: Animals; Sequence Homology, Amino Acid; Arylamine N-Acetyltransferase; Humans; Cricetinae; Mice; Protein Structure, Tertiary; Substrate Specificity; Cells, Cultured; Isoenzymes