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Journal article

Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion.

Abstract:

BACKGROUND: Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away from the sarcolemma to limit fatty acid uptake when fatty acid oxidation is inhibited. METHODS AND RESULTS: Wistar rat hearts were perfused during preischemia, low-flow ischemia, and reperfusion, using (3)H-substrates for measurement of metabolic ...

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Publication status:
Published

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Authors


Heather, LC More by this author
Atherton, HJ More by this author
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Journal:
Circulation. Heart failure
Volume:
6
Issue:
5
Pages:
1058-1066
Publication date:
2013-09-05
DOI:
EISSN:
1941-3297
ISSN:
1941-3289
URN:
uuid:de39f23a-c621-4ad4-9c86-ff26f070b416
Source identifiers:
418142
Local pid:
pubs:418142

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