- Abstract:
-
Size-dependent protein segregation at the cell-cell contact interface has been suggested to be critical for regulation of lymphocyte function. We investigated the role of ligand dimensions in regulation of mouse NK-cell activation and inhibition. Elongated forms of H60a, a mouse NKG2D ligand, were generated and expressed stably in the RMA cell line. RMA cells expressing the normal size H60a were lysed efficiently by both freshly isolated and IL-2 stimulated C57BL/6 mouse-derived NK cells; how...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.201040335
-
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- Journal:
- European journal of immunology
- Volume:
- 40
- Issue:
- 7
- Pages:
- 2050-2059
- Publication date:
- 2010-07-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:de26f508-c412-469c-aa90-a6b93495bc04
- Source identifiers:
-
54668
- Local pid:
- pubs:54668
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Ligand dimensions are important in controlling NK-cell responses.
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