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Ligand dimensions are important in controlling NK-cell responses.

Abstract:

Size-dependent protein segregation at the cell-cell contact interface has been suggested to be critical for regulation of lymphocyte function. We investigated the role of ligand dimensions in regulation of mouse NK-cell activation and inhibition. Elongated forms of H60a, a mouse NKG2D ligand, were generated and expressed stably in the RMA cell line. RMA cells expressing the normal size H60a were lysed efficiently by both freshly isolated and IL-2 stimulated C57BL/6 mouse-derived NK cells; how...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201040335

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Journal:
European journal of immunology
Volume:
40
Issue:
7
Pages:
2050-2059
Publication date:
2010-07-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:de26f508-c412-469c-aa90-a6b93495bc04
Source identifiers:
54668
Local pid:
pubs:54668

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