Journal article icon

Journal article

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.

Abstract:

Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are selectively enriched in the Argonaute/miR-182 complex and miR-182 downregulates BRCA1 expression. Antagonizing miR-182 enhances BRCA1 protein levels and protects them from IR-induced cell death, while overexpressing miR-182 reduces BRCA1 protein, impairs homologous recombination-mediated repair, and render cells hyperse...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Panchakshari, R More by this author
Gottipati, P More by this author
Expand authors...
Journal:
Molecular cell
Volume:
41
Issue:
2
Pages:
210-220
Publication date:
2011-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:de10733d-e279-4615-9910-f6e3a4ea10e9
Source identifiers:
125316
Local pid:
pubs:125316

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP