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Journal article

Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms

Abstract:

Epidemiological studies show that type 2 diabetes (T2D) is inversely associated with intracranial aneurysms (IA) and abdominal aortic aneurysms (AAA). Although adiposity has not been considered a risk factor for IA, there have been inconsistent reports relating adiposity to AAA risk. We assessed whether these observations have a genetic, causal basis. To this end, we extracted genotypes of validated single-nucleotide polymorphisms associated with T2D (n=65), body mass index (BMI) (n=97) and w...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ejhg.2017.48

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
European Journal of Human Genetics Journal website
Volume:
25
Issue:
6
Pages:
758-762
Publication date:
2017-04-05
Acceptance date:
2017-02-07
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Pubs id:
pubs:688001
URN:
uri:de0a2fb1-5b5c-4897-86ba-b6c19e6f144f
UUID:
uuid:de0a2fb1-5b5c-4897-86ba-b6c19e6f144f
Local pid:
pubs:688001
Paper number:
6
Language:
English

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