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Journal article

BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.

Abstract:

Numerous human genome instability syndromes, including cancer, are closely associated with events arising from malfunction of the essential recombinase Rad51. However, little is known about how Rad51 is dynamically regulated in human cells. Here, we show that the breast cancer susceptibility protein BRCA2, a key Rad51 binding partner, coordinates the activity of the central cell-cycle drivers CDKs and Plk1 to promote Rad51-mediated genome stability control. The soluble nuclear fraction of BRC...

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Publication status:
Published

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Journal:
Cell reports
Volume:
7
Issue:
5
Pages:
1547-1559
Publication date:
2014-06-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:de01210e-c02a-4332-9ecd-b38acbc5861c
Source identifiers:
466111
Local pid:
pubs:466111
Language:
English

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