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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.

Abstract:

The human tumor suppressor gene PTEN encodes a putative cytoskeleton-associated molecule with both protein phosphatase and phosphatidylinositol 3,4,5-trisphosphate (PIP3) 3-phosphatase activities. In cell culture, the lipid phosphatase activity of this protein is involved in regulating cell proliferation and survival, but the mechanism by which PTEN inhibits tumorigenesis in vivo is not fully established. Here we show that the highly evolutionarily conserved Drosophila PTEN homolog, DPTEN, su...

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Publication status:
Published

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Publisher copy:
10.1101/gad.13.24.3244

Authors


Journal:
Genes and development
Volume:
13
Issue:
24
Pages:
3244-3258
Publication date:
1999-12-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:ddfda777-c73d-4201-8280-5b81b3f18ef2
Source identifiers:
113734
Local pid:
pubs:113734

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